[Editor's Note: This article was originally published in October 2013 but has been updated for accuracy and comprehensiveness.]
Women are roughly three times more likely than men to experience migraines, about 17% of women versus 6% of men in the U.S. The main driver is the interaction between the hormone estrogen and a pain-signaling protein called CGRP: when estrogen drops or fluctuates, CGRP activity rises and the brain's threshold for a migraine attack falls.
That's the short answer. The...
